Khoekhoen (singular Khoekhoe) (or Khoikhoi in the former orthography; formerly also Hottentots, a term now considered offensive) are the traditionally nomadic pastoralist indigenous population of southwestern Africa. They are often grouped with the hunter-gatherer San (literally "Foragers") peoples. The designation "Khoekhoe" is actually a kare or praise address, not an ethnic endonym, but it has been used in the literature as an ethnic term for Khoe-speaking peoples of Southern Africa, particularly pastoralist groups, such as the !Ora, !Gona, Nama, Xiri and ǂNūkhoe nations.

While the presence of Khoekhoen in Southern Africa predates the Bantu expansion, according to a scientific theory based mainly on linguistic evidence, it is not clear when the Khoekhoen began inhabiting the areas where the first contact with Europeans occurred (possibly in the Late Stone Age). At that time, in the 17th century, the Khoekhoen maintained large herds of Nguni cattle in the Cape region. They mostly gave up nomadic pastoralism in the 19th to 20th century.

Their Khoekhoe language is related to certain dialects spoken by foraging San peoples of the Kalahari, such as the Khwe and Tshwa, forming the Khoe language family. The main Khoekhoe subdivisions today are the Nama people of Namibia, Botswana and South Africa (with numerous clans), the ǂNūkhoeǃhaos of Namibia, the !Orana clans of South Africa (such as ǀHõakhoena or AmaNgqosini), the Xirikua or Griekwa nation of South Africa, and the AmaGqunukhwebe or !Gona clans which fall under the Xhosa-speaking polities.

The Xirikua clans (Griqua) developed their own ethnic identity in the 19th century and settled in Griqualand. They are related to the same kinds of clan formations as the Rehoboth Basters, who could also be considered a "Khoekhoe" people.